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It has further surprisingly and unexpectedly been found that multiple agent therapy, such as wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, with higher reliability than does a higher dose of either agent administered as monotherapy that in some instances produces the desired pharmacological response

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R., Chamessian, A

While clinical data indicate that patients can achieve a 10% to 15% reduction in their total body weight over a year of consistent use, the initial phases require patience