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If the etiology of the oral pigmentation cannot be clinically established, a tissue biopsy is warranted for definitive diagnosis
However, our data suggest that following GSH depletion, NRF2 is stabilized, and this stabilization is associated with decreased expression of lipogenic enzymes and lower serum triglyceride levels
At the same time, although excitatory amino acids have no obvious effect, there is a decreasing trend, which can inhibit the expression of excitatory amino acid receptors, thereby weakening excitatory signal transduction and ultimately alleviating neurotoxicity
This temporal pattern suggests potential changes in reporting practices or drug utilization trends during the study period
J.ReijmanM
Theyve yet to really demonstrate that GLP-1 drugs can change the course of neurological disease
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