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Generally, after renal tubular epithelial cell injury, surviving renal tubular epithelial cells undergo dedifferentiation and proliferation to repair the damage [11]

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Chua and coworkers have reported that Sirt7 showed highly specific deacetylase activity on acetylated H3K18 peptide, and that Sirt7 also showed robust and specific H3K18Ac-deacetylase activity on full-length histone H3 in purified poly-nucleosomes 35