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Based on the STEP-1 clinical trial, the average weight loss with semaglutide 2.4 mg weekly is 14.9% of body weight over 68 weeks (about 16 months)

However, taking periodic breaks (2-4 weeks off after each cycle) may help maintain effectiveness and prevent potential tolerance

Overall treatment discontinuation rates due to adverse events were 6% (3 mg), 4% (12 mg) and 8% (36 mg) for orforglipron vs

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Per the brand's own contrast on its FAQ, prescription injectables work by directly activating GLP-1 receptors at levels far beyond what your body produces on its own

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