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By the 1960s, researchers had demonstrated the incretin effect the phenomenon where glucose taken orally triggers much higher insulin release than glucose given intravenously

Paul Grayson, a patient taking Ozempic for obesity, reported to NPR last year: Before Ozempic, I could consume a whole bottle of wine in an evening without trying real hard But with Ozempic, even one beer didnt feel good to me somehow. Many patients simply dont crave substances like they used to

GLP-1s were first prescribed to people with type 2 diabetes to stimulate the release of insulin from the pancreas and control blood sugar levels

Translation to human clinical application has been limited for both compounds

For those looking to manage their weight without injections, oral semaglutide treatment presents a compelling option

David, wheres the cool noise