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Deficiency in vitamin B 12 is associated with neurological, cardiovascular, psychological, hematological, and gastrointestinal disorders, many of which require clinical intervention and hospitalization

Betaine delays the onset of neurological impairment in nitrous oxide-induced vitamin B-12 deficiency in fruit bats

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All TrxR enzymes require an NADPH-dependent reduction step to exert their function in vivo and TrxR is a therapeutic target for cancer and infectious diseases 21,67

Cognition and neurodegeneration: In animal models, it enhanced resilience to brain ageing [14] and delayed the cognitive impairment, amyloid plaques, and inflammation associated with Alzheimers [15]