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Once that tissue grows, 11-beta-HSD1 activity inside the fat cells rises, converting more cortisone into active cortisol locally

Lockley SW, Skene DJ, Butler LJ, Arendt J

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Disruptions in this fragile equilibrium lead to metabolic and gastrointestinal diseases, highlighting the profound impact of the gut microbiota on the host intestinal metabolic processes

This ensures that while the specific compounded formulation hasnt gone through the same FDA brand-approval process, the facility making it is held to high federal safety and quality benchmarks