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Urticaria (Hives) What is it

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For the CagriSema combination, gastrointestinal adverse events affected 79.6% of participants compared to 39.9% with placebo

AI and AI-assisted tools statement During the preparation of this manuscript, the AI tool ChatGPT (GPT-5, released 2025-08-07) was used to generate Figure 1 and the Graphical Abstract and to improve the readability and language of the manuscript

Factors such as Persistent pancreatic pain leads to the chronic activation of the sympathetic nervous system and the hypothalamicpituitaryadrenal axis, which in turn leads to an increase of catecholamines and cortisol