Western blot data showed that metformin enhanced the nuclear translocation of Nrf2, and upregulated HO-1 expression in the cytoplasm (Fig
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While the condition is not a commonly listed side effect, it may be linked indirectly due to the drugs tendency to cause dehydration, fluctuations in blood sugar levels, risk of inflammation, and systemic effects on fluid balance
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Medicines with well-established links to gynaecomastia include spironolactone, digoxin, bicalutamide, GnRH analogues such as goserelin, finasteride, and certain antipsychotics such as risperidone
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