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If you are participating in a clinical trial, all side effects including gastrointestinal symptoms such as heartburn should be reported to the trial team as part of the pharmacovigilance process

The answer turned out to be surprisingly straightforward: Kennedy openly adm

SpringerBriefs in Pharmaceutical Science & Drug Development

Timing the increase for the follicular phase (days 1 through 14 of the cycle) can reduce the overlap between hormonal GI effects and dose-escalation GI effects

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In this way, the risk of regaining weight should be minimal