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doi: 10.1039/D1EN00651G 134 LiXRenMZhangXWangL

In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]

Sever'yanova L, Dolgintsev ME

Torreilles F, Salman-Tabcheh S, Gurin M-C, Torreilles J

doi: 10.1590/S1677-5538.IBJU.2015.02.07 77 KessopoulouEPowersHJSharmaKKPearsonMJRussellJMCookeIDet al

The closest analog (cagrilintide + semaglutide) has Phase 3 data showing meaningful additive benefit over semaglutide alone