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The honest answer is that it depends on the indication, and the timeline varies enough between tissue types that a single number is misleading

Vitamin B12 should be supplemented in vegetarians who do not get adequate amounts of B12 from diet or patients consuming a low calorie/low protein diet

The biomarker was scaled (Eib) according to the following function: i individual, b biomarker determined, E ib scaled value of the biomarker calculated based on reference values, V ib Value of the biomarker obtained from the determinations, Min b Lower limit of the biomarker reference value, Max b Upper limit of the biomarker reference value Data screening The total study population comprised 22 individuals

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Moreno MU, San Jos G, Fortuo A, Beloqui O, Redn J, Chaves FJ, et al

Baudouin-Cornu P et al