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1/Smad2/3 axis, a key pathway in fibrosis and epithelial-mesenchymal transition, thus reducing tissue fibrosis and promoting regenerative over fibrotic repair 4

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Reactive oxygen species (ROS)-induced alterations of the immune response has been proposed as a key player in COVID-19 pathogenesis and antioxidant intervention with NAC recommended as a preventive and therapeutic strategy (De Flora et al., 2020