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BENESCH RE et al
(Reference Mager3)
How the antioxidant role of -glutamylcysteine is regulated under (patho) physiological conditions now needs to be deciphered
Blots were developed using ECL kit (Thermofisher) or scanned using the OdysseyIR scanner (Li-CORBiosciences, NE)
However, due to modern lifestyle challenges, natural production alone may not always be enough
Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways
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