For example, administration of 2.4 mg/week of semaglutide (instead of 1 mg used in diabetics) for 68 weeks leads to average losses of 15% of initial body weight, approximately double that in type 2 diabetics (Figure 5A)
Semaglutide works by mimicking the GLP-1 hormone to reduce appetite and is available through specialist NHS services, while berberine is sold over the counter without any requirement to prove efficacy
[PMID: 29949490] doi: 10.1056/NEJMp1802313 Lingvay I , Capehorn MS , Catarig A-M , et al
Abdurrahman Tufan, Gazi University, Turkey Updates Copyright 2021 Huang, Fu, Chen, Li, Huang and Liang
Nutr Bull
Consider this scenario: a patient who loses their target weight in 12 months on tirzepatide at $350 per month (compounded) versus 18 months on semaglutide at $250 per month (compounded) ends up spending roughly $4,200 versus $4,500 total, despite tirzepatides higher monthly price