Diabetes Care 42(12):22722281 Rosenstock J, et al (2019) Effect of additional oral semaglutide vs sitagliptin on glycated hemoglobin in adults with type 2 diabetes uncontrolled with metformin alone or with sulfonylurea: the PIONEER 3 randomized clinical trial
Plasma concentrations of insulin and leptin were measured using a custom developed Mesoscale (MSD) multiplex assay, which is a multi-array assay with electrochemiluminescence readout
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These variations significantly influence the role of GLP-1 in regulating islet function and glucose homeostasis
These diabetes-specific results mirror the pattern seen with CagriSema in REDEFINE 2, though direct comparison requires caution because the trial populations and designs differed