mycotoxins deplete glutathione levels depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells Oncology Reports

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Authors proposed a model wherein PL enters the cell, is hydrolyzed in its active form (hPL) with subsequent formation of a hPL:GSH complex that binds the active site of GSTP1-1 causing its inhibition (Fig

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Glutathione synthesis is also supported by hepatic cysteine production via the transsulfuration pathway, which converts methionine to cysteine through homocysteine intermediates (7-8)

Researchers at Johns Hopkins Medicine have also shown that copper deficiency is associated with larger fat cells and altered lipid metabolism, adding to the growing evidence that copper plays an important role in maintaining healthy metabolic function

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