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Pairs Well MGF Pairs systemic IGF-1 receptor signalling with local satellite-cell activation - complementary mechanisms behind muscle hypertrophy research

The GLP-1RA are limited to use in individuals without established cardiovascular disease which limits the use widely but provides its benefit for at risk population

GLP-1 drugs are a clear example: They target a single signaling system yet can help improve obesity, diabetes, heart disease and kidney disease all at once

More specifically, this helps regulate: Appetite and satiety Food intake and cravings Insulin secretion in response to meals Rate of gastric emptying GLP-1 receptor agonist medications mimic this hormone and act on the brain and gut to reduce hunger, slow digestion, and improve blood sugar management

doi: 10.1016/j.jhepr.2025.101363 90