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Yet federal regulators have delayed or failed to adopt measures designed to reduce deaths and injuries from acetaminophen overdose, which the agency calls a persistent, important public health problem. The FDA has repeatedly deferred decisions on consumer protections even when they were endorsed by the agencys own advisory committees, records show

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Indeed, circadian rhythms are critical for bone homeostasis, as reflected by the diurnal fluctuations in bone remodeling markers from mice to humans (81)