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Sometimes a dose adjustment is necessary

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The Mesolimbic System: Lowering the Reward Volume If the hypothalamus regulates the homeostatic stomach hunger that tells you your body needs fuel, you can think of the mesolimbic system as driving your hedonic brain hunger. The mesolimbic system includes the ventral tegmental area (VTA) and nucleus accumbens (NAc)

If storage and dosing are confirmed correct, you may need to escalate to the next dose level

Neuen BL, Ohkuma T, Neal B, Matthews DR, de Zeeuw D, Mahaffey KW, et al