NICE recommends that treatment with these medications can continue for up to 2 years in specialist services
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The characteristic changes of GLP-1 face include 4,5 : Facial volume loss, particularly in the midface Periocular hollowing and periorbital volume depletion Dermal thinning with loss of collagen and elastin fibers Decreased skin elasticity leading to redundant skin folds Accelerated appearance of aging As a result of these facial changes, GLP-1 agonist medications can result in an older, haggard and tired looking appearance
doi:10.1016/j.metabol.2013.08.003 Nauck MA et al
Diabetes 48:754757 Fonseca SG, Urano F, Weir GC, Gromada J, Burcin M (2012) Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion
Individuals with G6PD Deficiency In those with this genetic red blood cell disorder, glutathione supplementation may lead to hemolytic crises