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A Narrative Review of Cardiovascular Outcome Trials

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Safety in TRIUMPH-1 The safety profile was consistent with incretin-class therapies: Most common AEs (12 mg dose): - Nausea: 42.4% - Diarrhea: 32.0% - Constipation: 26.1% - Vomiting: 25.3% Dysesthesia (a sensory disturbance tingling, numbness) and urinary tract infections were reported in approximately 10% of patients on the highest doses, but were generally mild to moderate and mostly resolved during treatment

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While it is helpful, it relies on your bodys internal machinery to assemble the final molecule, which can be slow

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Quick improvements in blood sugar can trigger temporary worsening of diabetic retinopathy Changes in blood flow to your optic nerve may increase risk for certain conditions Fluid shifts can temporarily blur your vision as your eyes adjust to better glucose control Pre-existing damage to retinal blood vessels may progress more quickly during early treatment Several GLP-1 receptor agonists are currently prescribed for diabetes and weight management

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