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According to the previous reports, LPS can bind to the TLR-4 on the glial cells, activate the NF-B pathway to trigger inflammatory responses, and subsequently facilitate the secretion of TNF- and IL-6 (89)

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(28) There were no statistically significant differences in amputation risk between GLP-1s, SGLT-2 inhibitors, DPP4-Is, and all other agents

The complexity arises from the individual mechanisms of action of each substance

Figure 1 It is well known that the pharmacodynamic property of metformin is anti-diabetic, but there is growing evidence that it has a number of extra-hypoglycemic effects