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Genetic and environmental triggers modulating the activation and regulation of the immune system (i.e., Th2 immune response) are the main orchestrators in the pathophysiology of asthma
By contrast, PD, which also has a prolonged prodromal stage similar to AD before the onset of motor symptoms, has a different progression of Lewy body pathology, which may take another decade to pervade the entire brain and cause significant, widespread neurodegeneration [102]
So even within KLOW, the evidence is uneven: strongest for the anchor, progressively more speculative for the supporting peptides
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