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GLP-1 receptors are expressed throughout the brain, particularly in the hypothalamic arcuate nucleus, the paraventricular nucleus, the area postrema, the nucleus tractus solitarius, and within dopaminergic reward circuitry

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Early Signs and Symptoms of Vitamin B12 Deficiency: Fatigue, weakness, and lack of energy: These symptoms may be brought on by inadequate vitamin B12, which lowers the synthesis of red blood cells

[9] [10] Several factors may explain why some individuals experience fatigue whilst taking GLP-1 medications: Reduced caloric intake : The appetite-suppressing effects can lead to significantly lower food consumption, potentially resulting in inadequate energy intake, particularly if patients are not consuming balanced, nutrient-dense meals