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This also facilitates albumin-binding and DPP-4 resistance, thereby allowing a half-life of 13 h (129)

A meta-analysis of 27,729 participants found the overall rate of GI side effects to be 11.66%

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Additional proposed mechanisms include improved myocardial energetics, reduced inflammation, and attenuation of cardiac remodeling, although the relative contribution of each pathway remains uncertain [33,34,35]

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