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Important limitations of the COBRRA trial were that it was open-label, followed-up patients for only three months, and excluded some important groups, including patients with active cancer and those weighing more than about 265 pounds

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What we do have is a narrow slice of human data from one proof-of-concept clinical trial [3] , early-phase pharmacokinetic work in healthy volunteers [2] , and a set of theoretical concerns from ipamorelin's mechanism that have not been observed in humans but follow logically from what the compound does