Also, we should emphasize the relative paucity of the BPC 157 clinical data (Seiwerth et al., 2018
Epp O, Ladenstein R, Wendel A (1983) The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution
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IGF-1 LR3 differs from endogenous IGF-1 in one critical way: the arginine substitution at position 3 prevents binding to IGF-binding proteins (IGFBPs), extending circulation time and allowing the peptide to remain bioavailable far longer than native IGF-1
However, gastrointestinal reactions also increased accordingly, suggesting a practical trade-off between dose-response and tolerability
Willshire C, Buckley RJ, Bron AJ