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doi: 10.1016/j.cell.2013.10.029 133 SimoesRVSerganovaISKruchevskyNLeftinAShestovAAThalerHTet al
Post-trial follow-up data from EMPA-KIDNEY suggest that cardiorenal benefits may persisted for up to 1 year after treatment cessation, highlighting the importance of continued therapy for long-term effectiveness [117]
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This allows the body to consolidate gains and reduces any theoretical long-term risks from extended continuous use
Microbial metabolites, including bile acid derivatives and short-chain fatty acids (SCFAs), can influence endogenous GLP-1 secretion and activity
That said, researchers may find it useful to have a bit of background on past GHK-Cu dosing protocols: Minimum Effective Dose The lowest known doses of GHK-Cu administered to test subjects involve the application of skin creams and topical ointments
