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Indeed, we observed that 3NP treatment induced a significant increase in neuronal apoptotic death in the striatum, as judged by TdT-mediated dUTP nick end labelling assay, in the mice pre-injected with inactive mito GCL (E103A), but not in those pre-injected with wild-type mito GCL (Fig

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This gives Mounjaro a slight advantage in achieving faster weight-loss results. In a head-to-head clinical trial, Lilly reported that tirzepatide led to an average weight reduction of 20.2%, compared to 13.7% with semaglutide after 72 weeks of treatmenta 47% greater relative weight loss with tirzepatide