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If any step breaks down (low stomach acid, lack of intrinsic factor, or gut inflammation), much of the B12 passes through unabsorbed

Individuals recovering from bariatric surgery , where nutrient malabsorption is common

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Osteoporosis Osteoporosis is a metabolic bone disease characterized by low bone mass and degeneration of bone tissue microstructure, leading to increased bone fragility and susceptibility to fractures