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On the origin of cancer cells
164 In addition, hyperglycemia and other metabolic disorders such as dyslipidemia, inflammatory factors, excess IAPP and alterations in the gut microbiota, combine to contribute to IR and/or cell dysfunction through the common pathways of inflammation, ERS and oxidative stress (Fig
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Indeed, experimental analysis showed that introduction of doxorubicin into physiologically relevant pH media yielded a concentration-dependent oxygen consumption profile, revealing free (non-metal catalysed) auto-oxidation (Fig
M., Chapple, C
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