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Some diabetes-related blood pressure medications (like diuretics or beta-blockers) can also affect fluid balance or heart rate, further complicating the bodys heat response

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In a prospective study of T2DM patients, six months of liraglutide therapy improved diastolic function and reduced left ventricular mass index [44], while additional echocardiographic studies have reported improvements in global longitudinal strain and left ventricular mass with GLP-1 receptor agonists [45]

Research has documented measurable increases in resting metabolic rate in animal models, attributed primarily to the glucagon receptor component