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The short answer is an unequivocal, absolute yes
Riddle MC, Forst T, Aronson R, Sauque-Reyna L, Souhami E, Silvestre L, et al
Candidates for sustained therapy typically have genetic predispositions to obesity, a history of rapid weight regain after prior dieting, metabolic syndrome, or appetite-regulation disorders
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He speculates that GLP-1 receptors in some people may have genetic differences that might influence how well the hormone binds to the receptor and activates subsequent insulin and satiety pathways
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