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Effective at lowering HbA1c and may help non-alcoholic fatty liver disease, but causes weight gain, fluid retention (avoid in heart failure), and an increased fracture risk

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The question is whether the net effect is positive or negative, and the aggregate clinical data strongly suggests it is positive for most people

Preclinical study in mice with streptozotocin-induced diabetes that showed glucose-independent amelioration of kidney fibrosis with the DPP-4 inhibitor linagliptin