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Preclinical studies further demonstrate that combining PPR with donepezil enhances therapeutic efficacy in AD rat models by improving synaptic plasticity, reducing oxidative stress, and ameliorating histopathological outcomes (36)
80 Animal and human studies have also shown that gut microbiota can be involved in the regulation of chemical signals involved in stress and anxiety (eg, serotonin and cortisol), which implicate a role for probiotics in managing these conditions
GLP-1s have also been reported to interfere with birth control
Most data comes from preclinical studies and off-label observations
Limitations No overnight changes results, if any, emerge over several weeks
Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)
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