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When these pro-inflammatory mediators reach the hypothalamus, they increased the levels of oxidative stress and neuronal inflammation in the hypothalamus through processes such as microglia proliferation (124, 125)

Moreover, the availability of multiple effective obesity pharmacotherapies with different mechanisms of action will provide clinicians the opportunity to select treatments based on patient preference, underlying comorbidities, medication safety profile and treatment response, with an aim to achieve the individualised WL targets, improve the overall health and/or the quality of life [7]

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Ramsay is a recipient of scholarships from the National Health and Medical Research Council of Australia, the Cancer Institute New South Wales, and the Translational Cancer Research Network

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