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For the groups in the 6-OHDA + drug category, the rats were intraperitoneally injected with 10 nmol/kg body weight of the respective drug once daily for 30 days (as seen in Figure 1 )

MK 677, or Ibutamoren, is a compound that stimulates growth hormone release by mimicking the action of ghrelin

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IL-1 enhances MMPs production and the adhesion of leukocytes to RA FLS by activating ERK, c-Jun N-terminal kinase (JNK), apetala (AP)-1, and NF-B (73, 74)

For women, E 2( t ), varies from 0.135 to 1.156 nM over the course of the cycle [24,25] , and for men, E2 is a constant 0.09 nM [26]