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For individuals with a history of severe hypersensitivity reactions, referral to an allergy or immunology specialist may be appropriate before initiating treatment

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved these medications for glycaemic control and weight management, not as primary anti-inflammatory agents

The injection is given under the skin of the abdomen, thigh, or upper arm once every week

Corticosteroids, particularly when used at moderate to high doses or for prolonged periods, can cause significant metabolic effects that may counteract weight loss efforts

Retatrutide is a once-weekly injectable medication developed by Eli Lilly that has shown promise in the treatment of obesity and type 2 diabetes

Subst Use Misuse 45:17421765 Rentzeperi E, Pegiou S, Koufakis T et al (2022) Sex differences in response to treatment with glucagon-like peptide 1 receptor agonists: opportunities for a tailored approach to diabetes and obesity care