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Further studies showed that lysine acetyltransferase 8 (KAT8) was responsible for self-RNA-driven H4K16ac modification and psoriasis-associated pathogenic chemokine expression in macrophages of lesional skin

With respect to metastatic competence, studies using in vitro models have shown that ROS are associated with EMT-related marker changes (e.g., decreased E-cadherin), extracellular matrix remodeling (LOX), and regulation of MMPs, which can enhance migration and invasion programs

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Role of copper and ceruloplasmin in oxidative mutogenesis induced by the glutathione--glutamyl transpeptidase system and by other thiols