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While outright deficiency is rare, especially in healthy individuals who consume a varied diet, certain signs can indicate low levels of L-Carnitine, such as muscle weakness, fatigue, or difficulty in achieving peak physical performance

Some experimental models report preserved mitochondrial density even in advanced HF, and it is unclear whether structural injury precedes or follows contractile dysfunction

Chen Z, Zuo X, He D et al

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Linani et al., 2022)

The combined metabolic footprint would be broader than either compound alone, touching more systems through more pathways