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Three RCTs met inclusion criteria The trials randomized 153 participants (74 participants to oral vitamin B12 and 79 participants to IM vitamin B 12 )

General Safety Profile Based on the preclinical dataset and the limited human exposure data: No prominent signal of hepatic, renal, or hematological toxicity at tested doses No prominent cardiovascular safety flag Pregnancy and lactation as with most research compounds, safety not established Long-term effects not characterized What Clinicians Should Actually Tell Patients For patients asking about 5-amino-1MQ, a reasonable response framework: What the compound is: A research-stage small molecule inhibiting NNMT with promising preclinical fat loss data

Lipo B12 injections work differently than oral B12 supplements

Blocking NNMT activity has been shown in research settings to influence body composition, leading to reduced adipocyte size, alterations in fat mass, and measurable changes in plasma biomarkers such as glucose and cholesterol

My body fat percentage is still relatively high

S2CID 4978703