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Beta-blockers like propranolol manage sympathetic symptoms of hyperthyroidism but do not significantly lower basal metabolic rate

However, neither the innate nor the adaptive immune response is affected by the DPP-4 inhibitors being used clinically (128), and reassuringly, there is no evidence for any increased risk of infections in the pooled safety analyses (119123) or in the CV safety outcome trials (125127), in line with the view that the catalytic activity of DPP-4 is not necessary for the co-stimulatory role of CD26 in T-cell activation

Semaglutides cardiovascular benefit data (the SELECT trial, 2023) remains a distinct advantage for high-risk patients, and this consideration may guide some providers to recommend semaglutide even for patients currently on tirzepatide

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Their medical use remains under evaluation, and clinical guidance is necessary before considering them for skin health purposes

doi: 10.1016/j.medp.2024.100027 71 DaoT.LinthorstH.VerpoorteR