VK2735 Research# VK2735's evidence base consists of phase 2 trials: VENTURE (subcutaneous): 176 adults with obesity, 13 weeks, up to 14.7% weight loss from baseline (placebo-adjusted 13.1%) VENTURE-Oral: Oral tablet formulation, 13 weeks, up to 12.2% weight loss vs 1.3% placebo Phase 3 VANQUISH program: Planned but not yet initiated at time of writing Evidence level: Low -- promising phase 2 data only, short duration, small sample sizes, no head-to-head comparisons
Side effects tend to include mild to moderate gastrointestinal issues like vomiting, diarrhea, nausea, and constipation
10.1016/j.psyneuen.2011.04.012 6 AsadiS.GholamiM
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de Ligny et al
Kahn, Metabolites as regulators of insulin sensitivity and metabolism