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These findings establish the mechanistic basis for the compound and provide proof of concept for its metabolic effects

In multiple pathological settings, affected cells are not distributed randomly, but instead form contiguous zones of degeneration, synchronized tubular epithelial loss, aligned myofiber injury, or expanding fronts of tissue damage, patterns that are difficult to reconcile with strictly cell-autonomous execution

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Topological analysis identified the top 10 key targets: IL1B, IL6, TNF, AKT1, CASP3, MAPK3, BCL2, TGFB1, MMP9, and PPARG

95% CI: 0.610.91

Moreover, L-carnitine co-administration confers partial nephroprotection in mice treated with colistin, without interfering with its pharmacokinetics and antibacterial activity