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L-Carnitine has been used by athletes for a long time as a dietary supplement for weight loss and muscle definition with much success

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The sustained effects of a dual GIP/GLP-1 receptor agonist, NNC00902746, in patients with type 2 diabetes

The combination of reduced food intake (and therefore reduced water from food) plus potential gastrointestinal effects means dehydration is a real risk

Debatable Pro / Con: increased arrousal, more actively sexually active