While these medications are not primarily classified as hormonal therapies, their metabolic effects inevitably intersect with endocrine function, particularly in patients with obesity and insulin resistanceconditions known to disrupt multiple hormonal axes
This weight loss is possible due to the additive effect of targeting multiple hormone pathways involved in energy homeostasis, namely GLP-1 and GIP receptor pathways
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MMA levels should be interpreted with caution in individuals with renal failure because this situation is associated with elevated levels of this biomarker [14]
Its role as a fat transporter supports metabolic engagement by mobilizing stored fat for energy use, potentially supporting patients in developing leaner physiques over time when combined with appropriate diet and exercise
Additionally, these medications influence gut motility more broadly, potentially altering intestinal transit time