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10 The first step in the biosynthesis of GSH is rate-limiting and is catalysed by glutamate-cysteine ligase (GCL)
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Various modulators, such as LONP1 [56], SMAD4 [57], Thiostrepton (TST) [58], verteporfin [59], and tomatidine [60], regulate GPX4 expression at the transcriptional level to induce ferroptosis in PDAC cells
Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells
Glutathione is a molecule our bodies produce naturally to cleanse free radicals and toxins from our system
A healthy control is included to demonstrate the fidelity of the populations
