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In addition, P53 can also inhibit system Xc- uptake of cystine by downregulating the expression of SLC7A11, thereby affecting the activity of GPX4, resulting in a reduction in cell antioxidant capacity, accumulation of lipid ROS, and ferroptosis 10,11
However, the evidence is modest , especially for cosmetic uses like skin-whitening, and the side-effects , while usually mild, must be taken seriously especially in certain populations (asthma, pregnant, on chemotherapy, etc.)
Eur J Pain .May 2024;28(5):821-830
Aaghaz, S., Gohel, V
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