If the main drivers are stress physiology, under-eating, gut inflammation, thyroid dysfunction, nutrient deficiencies, sleep disruption, or adrenal dysregulation, appetite suppression is not the best first move and may do harm
Naturally, I gained quite a bit of weight with each pregnancy
Normal aging is associated with reduced sleep duration, lighter and more fragmented sleep, increased nocturnal awakenings, and a shift toward earlier wake times
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In DECLARE-TIMI58 with dapagliflozin, 4.4% of the patients were using GLP-1RAs at baseline, and dapagliflozin reduced the risks of MACE, HHF, and composite kidney outcomes regardless of baseline GLP-1RA use [49]
Worth noting: 16% is in the ballpark of the amount of weight most people lose on semaglutide